Ciprofloxacin logp value

Abstract

Objectives

To evaluate the relationship between ciprofloxacin injection and drug-induced pulmonary hypertension in a tertiary care center.

Methods

Data were collected from the medical records of patients who have received an oral ciprofloxacin injection from the first month of their stay at a tertiary care center in the United States (2023). All patients were given a single intravenous (IV) ciprofloxacin injection. The median dose of ciprofloxacin injection was 500 mg and the median dose of the drug was 1,000 mg/day. The median number of doses of ciprofloxacin injection and the median number of ciprofloxacin injection-related adverse events were 14 and 8, respectively.

Results

A total of 12,534 patients were included in the analysis of the primary analysis, including 18,927 who were received ciprofloxacin injection and 1,988 who received no ciprofloxacin injection. There were a total of 787 patients who were administered the drug and an additional 992 patients received an additional 12,534 doses of ciprofloxacin injection. The median duration of ciprofloxacin injection was 21 days. The median number of doses of ciprofloxacin injection-related adverse events was 6 and 1,521,943,638. Of the patients receiving ciprofloxacin injection, 8,038 (37.6%) developed a pulmonary edema while the median number of doses of ciprofloxacin injection-related adverse events was 1. The median time to pulmonary edema was 8.8 days for the ciprofloxacin injection group and 3.4 days for the drug group. The median time to pulmonary edema was 5.3 days for the ciprofloxacin injection group and 2.4 days for the drug group.

Conclusions

In the first month of ciprofloxacin injection, the median ciprofloxacin injection-related adverse events were more commonly observed for the ciprofloxacin injection group than for the other groups, and these adverse events were significantly higher in the ciprofloxacin injection group than in the other groups. These results suggest that the use of ciprofloxacin injection in a tertiary care center can be beneficial for patients with pulmonary edema who are receiving a single intravenous ciprofloxacin injection.

Cite

John M. B. Sonderman, MD;Steven J. Wojcik, MDDalia R. SjöströA. K. Sørensen, MDS. P. H. Oskanen, MDM. G. Sønningen, MDJ. Ullrich, MDRømland, MDNielsen, MDJensen, MDAndersen, MDJanssen, MDI. V. O'Neill, MDR. Beyring, MDE. Egan, MDTiefer, MDBhatt, MDC. Reiss, MDJenssen, MDVos, MDD. Smith, MDKnecht, MDHousman, MDGann, MDT. Eelaide, MD

Ciprofloxacin and Other Antibiotics

If you have or ever have a medical problem that you may not realize is related to your medication, then Ciprofloxacin is a drug that is used to treat infections caused by bacteria. It is also used to treat certain types of bacterial infections. The drug is usually given to children between the ages of 8 and 18, but it is also commonly used to treat certain types of pneumonia. Ciprofloxacin is a fluoroquinolone, which means that it is a fluoroquinolone antibiotic. Ciprofloxacin is available as a capsule and tablet, but it can also be given by injection.

Fluoroquinolones are powerful antibiotics that work by killing or stopping the growth of bacteria. They are commonly used to treat a wide range of bacterial infections. Ciprofloxacin is usually given to children between the ages of 8 and 18, but it is also commonly used to treat certain types of pneumonia. Ciprofloxacin is available in both generic and brand name.

Ciprofloxacin is a broad-spectrum antibiotic that is used to treat a wide range of bacterial infections. It works by stopping the growth of bacteria in the body, making the immune system more effective, and making the immune system more likely to attack other organisms.

When a drug is taken by mouth, the body’s immune system attacks the body’s cells to kill them. It also kills other organisms, which can lead to infections.

If you have or ever have a medical problem that you may not realize is related to your medication, Ciprofloxacin is a drug that is used to treat infections caused by bacteria.

Ciprofloxacin and other antibiotics can be used to treat a wide range of bacterial infections.

Ciprofloxacin and other antibiotics

Indications

Treatment of bacterial infections of the lungs, nose, ear, bones and joints, skin and soft tissue, kidney, bladder, abdomen, and genitals caused by ciprofloxacin-susceptible organisms. Infections may include urinary tract infection, prostatitis, lower respiratory tract infection, otitis media (middle ear infection), sinusitis, skin, bone and joint infections, infectious diarrhea, typhoid fever, and gonorrhea.

Administration

May be taken with or without food. May be taken w/ meals to minimise GI discomfort. Do not take w/ antacids, Fe or dairy products.

Contraindication

Hypersensitivity to ciprofloxacin or other quinolones. History or risk of QT prolongation; known history of myasthenia gravis. Concomitant use with tizanidine.

Common side-effects

Vomiting, Stomach pain, Nausea, Diarrhea

Special Precaution

Patient with known or suspected CNS disorders, risk factors predisposing to seizures, or lower seizure threshold; history or risk factors for QT interval prolongation, torsades de pointes, uncorrected hypokalaemia/hypomagnesaemia, cardiac disease (e.g. heart failure, MI, bradycardia); positive family history of aneurysm disease, pre-existing aortic aneurysm or dissection and its risk factors (e.g. Marfan syndrome, vascular Ehlers-Danlos syndrome, hypertension, peripheral atherosclerotic vascular disease); diabetes, previous tendon disorder (e.g. rheumatoid arthritis), G6PD deficiency. Renal and hepatic impairment. Elderly, children. Pregnancy and lactation.

Storage

Store between 20-25°C.

MedsGo Class

Quinolones

Get a warning for use in children over 18 years of age when driving a motor vehicle, heavy machinery, or motorhome. This can be a risk factors for sudden breathing or throwing objects into the water or soil. This can be a risk factor for aspiration and/or infections. This can be a risk factor for QT interval prolongation (see Precautions section). This can also be a risk of QT interval prolongation (see Precautions section). This can also be a risk of QT prolongation (see Precautions section). Avoid use while expiring or in empty stomach. Use with caution in pregnant women. If you get an erection, you should not drive again, or use forceps, or use any other method of sexual stimulation, by mouth, or by swallowing. Do not give nitrates to person with hypertension or heart failure.

MedsGo class 6 drug: quinidine; includes mazofloxacin, diltmolol, levofloxacin, norfloxacin, norflurin, moxifloxacin, ofloxacin, norflurin, moxifloxacin, neflurin, nexacin, norfloxacin, tobramycin, timolol, tobramycin, timidol, levofloxacin, tobramycin, tobramycin extended release, and norflurin. This drug can be used to treat bacterial infections (e.g. urinary tract infection, respiratory tract infection, lower respiratory tract infection, urinary tract infection, skin infection, bone and joint infection).

Susceptibility to ciprofloxacin: known susceptibility. Category: Includes genotypes 3 and 4.

The following chart compares ciprofloxacin prices at CVS, Walmart, and Rite Aid, highlighting CVS’s prices at various retail outlets.

CVS(NYSE: CVS) posted a strong positive outlook for its ciprofloxacin price at its Rite Aid stores, while Walmart’s price was slightly higher than expected.

However, the retailer posted a worse-than-expected outlook for its price at CVS, while its other stores were selling lower-priced drugs. The retailer posted a slight increase in ciprofloxacin prices at all stores, while its other stores posted a slight increase.

“The overall outlook for CVS and other retailers is positive, with CVS holding a significant market position and Walmart holding a slight market share,” said Jim Czerny, chairman and chief executive officer of CVS. “CVS’s strong sales in 2012, 2013, and 2014 underscore its continued commitment to innovation and customer satisfaction.”

Rite Aid(NYSE: RTU) posted a strong outlook for its ciprofloxacin price at its Walgreens stores, while its other stores posted a slight increase.

Rite Aid posted a positive outlook for its ciprofloxacin price at Walgreens, while Walmart posted a slightly higher outlook.

“CVS continues to offer competitive pricing for ciprofloxacin, with prices at both the brick-and-mortar stores and chain stores reporting favorably,” said Dan Seiden, president and CEO of LiveScript. “We expect ciprofloxacin prices to remain stable at all retailers.”

(NYSE: CVS) posted a strong outlook for its ciprofloxacin price at its Rite Aid stores, while its other stores posted a slight increase.

Rite Aid posted a slightly higher outlook for its ciprofloxacin price at Rite Aid stores, while Walmart posted a slightly higher outlook.

“We’re very pleased with the positive outlook for our products for ciprofloxacin, but we’re looking further into the full-year ahead,” said Karen Czerny, chairman and chief executive officer of Rite Aid. “We’re looking forward to further expanding our footprint in the retail space.”

Walmart(NYSE: WOTC) posted a strong outlook for its ciprofloxacin price at its CVS stores, while its other stores posted a slight increase.

Walmart posted a slightly higher outlook for its ciprofloxacin price at Walgreens, while its other stores posted a slight increase.

Other retailers

Based on the full-year outlook for ciprofloxacin prices, as of December 31st, 2012, Walmart’s prices were at $1.074 a capsule, $1.072 a tablet, and $1.082 a caplet.

While the retail prices at Walgreens and Rite Aid were lower, the retailer posted a slightly higher outlook for its ciprofloxacin price at $1.099 and $1.1, respectively. The other retailers’ prices were slightly higher, at $0.97 and $0.87, respectively.

(NYSE: CVS) posted a strong outlook for its ciprofloxacin price at its Walmart stores, while its other stores posted a slight increase.

CVS posted a slightly higher outlook for its ciprofloxacin price at Walmart stores, while Rite Aid posted a slight increase.

Walmart posted a slightly higher outlook for its ciprofloxacin price at its Rite Aid stores, while Walmart posted a slight increase.

(NYSE: RTU) posted a strong outlook for its ciprofloxacin price at its Walgreens stores, while Walmart posted a slightly higher outlook.

Rite Aid posted a slightly higher outlook for its ciprofloxacin price at Walgreens, while Rite Aid posted a slight increase.

Uses of Ciprofloxacin+Tinidazole

The combination of Ciprofloxacin and Tinidazole is indicated for the management of a wide variety of infections caused by susceptible gram-positive and gram-negative organisms along with anaerobes and protozoa.

Therapeutic Category

Ciprofloxacin: Antibiotics (Quinolone antibiotics)

Tinidazole : Antiprotozoals

How Ciprofloxacin+Tinidazole works

Ciprofloxacin + Tinidazole effectively manages infection, where ciprofloxacin works by killing bacteria that cause infections. It only works with specific strains of bacteria. Tinidazole works by killing the parasites and anaerobic bacteria that are responsible for causing infections by damaging their DNA.

Common side effects of Ciprofloxacin+Tinidazole

  • diarrhoea
  • joint pain and inflammation
  • nausea, vomiting
  • loss of appetite
  • stomach pain or cramps
  • headache
  • vertigo (head spinning sensation)
  • skin rash or itching (especially affecting the whole body)

When to consult your doctor

Consult your doctor:

  • In case of accidental overdosage
  • If you experience severe, sudden allergic reaction with symptoms such as tightness in the chest, feeling dizzy, sick or faint or experience dizziness when standing up
  • If you experience muscle weakness, inflammation of the tendons which could lead to rupture of the tendon, particularly affecting the large tendon at the back of the ankle
  • If you experience serious life-threatening skin rash, usually in the form of blisters or ulcers in the mouth, throat, nose, eyes and other mucous membranes such as genitals which may progress to widespread blistering or peeling of the skin (stevens-jhonson syndrome, toxic epidermal necrolysis

Health Tips for Ciprofloxacin+Tinidazole

  • Take Ciprofloxacin + Tinidazole exactly as directed by your doctor. Follow the specified dosage and regimen. Do not change the dosage or discontinue the medicine without first consulting your doctor
  • Do not eat or drink any dairy products (such as milk or yoghurt) or drinks with added calcium when you take Ciprofloxacin + Tinidazole, as they may affect the absorption of this medicine. Also, do not drink wine, beer or spirits during treatment and for 3 days after stopping treatment with this medicine. Remember to drink plenty of fluids while you are taking this medicine
  • Avoid consumption of alcohol while taking Ciprofloxacin + Tinidazole
  • Do not drive or operate any machines while taking Ciprofloxacin + Tinidazole as it may make you feel less alert and cause neurological problems
  • Ciprofloxacin + Tinidazole should not be taken during pregnancy and during breastfeeding and for three days following the last dose as it may passes through breast milk
  • Ciprofloxacin + Tinidazole is not recommended for use in individuals with blood disorder or a history of blood disorders and peripheral neuropathy
Do this for as long as your doctor has prescribed it for you, to ensure that the recommended dosage is maintained or even20439/ormon/allergic/you have not yet taken it daily for a specific time period. He or she will decide how you are treated with every day.In case of an overdose: never take more than the prescribed dose without medical advice, but call your doctor for advice.